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Multicolor Quantum Dots Aid in Cancer Biopsy Diagnosis
Atlanta (July 6, 2010) — The tunable fluorescent nanoparticles known as quantum dots make ideal tools for distinguishing and identifying rare cancer cells in tissue biopsies, Emory and Georgia Tech scientists have demonstrated.
An article to be featured on the cover of the July 15 issue of Analytical Chemistry describes how multicolor quantum dots linked to antibodies can distinguish the Reed-Sternberg cells that are characteristic of Hodgkin’s lymphoma.
"Our multicolor quantum dot staining method provides rapid detection and identification of rare malignant cells from heterogenous tissue specimens,” says senior author Shuming Nie, PhD, the Wallace H. Coulter distinguished professor in the Coulter department of biomedical engineering at Georgia Tech and Emory University. “The clinical utility is not limited to Hodgkin’s lymphoma but potentially could be extended to detect cancer stem cells, tumor-associated macrophages and other rare cell types.”
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The Georgia Institute of Technology is one of the nation's premier research universities. Ranked seventh among U.S. News & World Report's top public universities, Georgia Tech's more than 20,000 students are enrolled in its Colleges of Architecture, Computing, Engineering, Liberal Arts, Management and Sciences. Tech is among the nation's top producers of women and minority engineers. The Institute offers research opportunities to both undergraduate and graduate students and is home to more than 100 interdisciplinary units plus the Georgia Tech Research Institute.