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Researchers Describe First Functioning "Lipidome" of Mouse Macrophage
Atlanta (December 21, 2010) — For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell - in this case, a mouse macrophage or white blood cell - but they also report how these lipids react and change over time to a bacterial stimulus triggering the cell’s immune response.
Writing in the December 17 issue of the /Journal of Biological Chemistry/, lead author Edward A. Dennis, PhD, distinguished professor of pharmacology, chemistry and biochemistry at the University of California San Diego School of Medicine, said the work culminates more than seven years of effort by scientists in LIPID MAPS, a national consortium of 12 research laboratories at nine “core” universities, medical research institutes and life sciences companies collaborating to study the structure and function of lipids. The laboratory of Dr. Al Merrill (School of Biology, Georgia Tech) was responsible for the sphingolipid analyses and characterization carried out by the consortium.
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The Georgia Institute of Technology is one of the nation's premier research universities. Ranked seventh among U.S. News & World Report's top public universities, Georgia Tech's more than 20,000 students are enrolled in its Colleges of Architecture, Computing, Engineering, Liberal Arts, Management and Sciences. Tech is among the nation's top producers of women and minority engineers. The Institute offers research opportunities to both undergraduate and graduate students and is home to more than 100 interdisciplinary units plus the Georgia Tech Research Institute.